Report Category. >> To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? Powder becomes slippery when wet. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. q9;v80q>jZ endstream 1. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Have an order or account question, find answers in our Online Support articles. Some substance identifiers may have been claimed confidential, or may . Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. A family of polysaccharide products that allow distinctive drug delivery solutions. Chemical Formula: (C6H10O5)n 1.4. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. FMC, JRS and Mingtai were estimated to hold for . msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, 51395-75-6 Avicel RC 591. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Quick Links. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. % The data shown below apply only to Avicel PH 101. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. The table below shows the most common physicochemical parameters of this raw material. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. ( <> Microcrystalline Cellulose / Avicel PH-102. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. undefined. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! It is . In extrusion-spheronisation, it is the excipient of choice. All Rights Reserved. Protect them from sunshine or rain. << Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. 9,LL!z These, in turn, are assembled into fibrils in the cell wall. endobj No. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. /Resources 2 0 R CAS #: 9004-34-6 . Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. 2008-2023 ChemPoint. Created Date: 2/10/2020 8:51:41 PM . Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . No. cas:9032-51-3 msds CELLULOSE PAB. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. };khd5x=fr Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Material safety data sheet - FMC Corporation. Request media, explore upcoming events and read our latest updates. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . ). ChemicalBook. Avicel RC-591 & CL-611 - Description. 2021 Annual Report. In large quantities it provides dietary bulk and may lead to a laxative effect. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. (&E. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. : 5. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. BIOACCUMULATIVE POTENTIAL Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Avicel Microcrystalline Cellulose Physical Properties. 1 0 obj IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Aqueous suspensions of microcrystalline cellulose have . }o]X4]. Origin(s): Plant/Botanical. Revision No. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. MATERIAL SAFETY DATA SHEET. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. l~5C High performance lubricant that brings more to the tablet. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Microcrystalline Cellulose (MCC) MSDS 1. Your file is uploaded and ready to be published. w !1AQaq"2B #3Rbr Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Magazine: Material safety data sheet - FMC Corporation. Avicel PC 611 (FMC Biopolymer) . All rights reserved. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. PDF (4.11 mb) Footer menu 1. %PDF-1.5 Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. It is a white, free-flowing powder. Product Name Cellulose microcrystalline. The short-term limit for total inhalable dust is 20 mg/m3. Avicel PH-200 microcrystalline cellulose NF, Ph. Fiber supplements can lessen the absorption of some . Avicel PH-101. % They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Microcrystalline Cellulose Side Effects. Find answers in our support articles. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. It . stream microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Cellulose microcrystalline. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. We know that our customers need to provide reliable and consistent products to their patients. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. ( on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. PharmaCentral 2021 . Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Eur., JPE . /Contents 4 0 R To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. The figure below illustrates the structural organisation of cellulose within plants. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg .
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